Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Heterogeneity in human immune responses is difficult to model in standard laboratory mice.
To understand how host variation affects Bacillus Calmette Guerin–induced (BCG-induced) …

At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Tuberculosis claims more human lives than any other infectious disease. This alarming
epidemic has fuelled the development of novel antimicrobials and diagnostics. However …

Tuberculosis is the most lethal infectious disease globally, but the vast majority of people
who are exposed to the primary causative pathogen, Mycobacterium tuberculosis (MTB), do …

Background The roles of host and pathogen factors in determining innate immune
responses to M. tuberculosis are not fully understood. In this study, we examined host …

A polymorphism causing deficiencies in Toll-interacting protein (TOLLIP), an inhibitory
adaptor protein affecting endosomal trafficking, is associated with increased tuberculosis …

After extensive exposure to Mycobacterium tuberculosis (Mtb), most individuals acquire
latent Mtb infection (LTBI) defined by a positive tuberculin skin test (TST) or interferon-γ …

Resistance to M. tuberculosis, often referred to as “RSTR” in the literature, is being
increasingly studied because of its potential relevance as a clinical outcome in vaccine …