Complex molecular mechanisms define our responses to environmental stimuli. Beyond the
DNA sequence itself, epigenetic machinery orchestrates changes in gene expression …

Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …

The notion that the germ line does not age goes back to the 19th-century ideas of August
Weismann. However, being metabolically active, the germ line accumulates damage and …

Amniogenesis—the development of amnion—is a critical developmental milestone for early
human embryogenesis and successful pregnancy,. However, human amniogenesis is …

Cancer cells and embryonic tissues share a number of cellular and molecular properties,
suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor …

Induced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the
promise for tissue replacement to counter age‐related decline. However, attempts to realize …

Clinical approval of the immune checkpoint blockade (ICB) agents for multiple cancer types
has reinvigorated the long-standing work on cancer vaccines. In the pre-ICB era, clinical …

Seizure disorders debilitate more than 65,000,000 people worldwide, with temporal lobe
epilepsy (TLE) being the most common form. Previous studies have shown that …

Faithful cellular differentiation requires temporally precise activation of gene expression
programs, which are coordinated at the transcriptional and translational levels. Neurons …

Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural
differentiation and maturation. We present a hiPSC transcriptomics resource on …