The mammalian skeletal system is densely innervated by both neural and vascular
networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The …

Neuromas are a substantial cause of morbidity and reduction in quality of life. This is not
only caused by a disruption in motor and sensory function from the underlying nerve injury …

Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone
remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed by …

Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly
regulated processes, with SSPC dysregulation leading to progressive bone disease. While …

Peripheral neurons terminate at the surface of tendons partly to relay nociceptive pain
signals; however, the role of peripheral nerves in tendon injury and repair remains unclear …

Although previous RNA sequencing methods have been widely used in orthopedic research
and have provided ideas for therapeutic strategies, the specific mechanisms of some …

Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in
areas of soft tissue. HO can develop as a consequence of traumatic insult or as a result of …

Heterotopic ossification (HO) is a pathological process resulting in aberrant bone formation
and often involves synovial lined tissues. During this process, mesenchymal progenitor cells …

Human blood vessel walls show concentric layers, with the outermost tunica adventitia
harboring mesenchymal progenitor cells. These progenitor cells maintain vessel …

Heterotopic ossification (HO) refers to the formation of pathologic bone in nonskeletal
tissues (including muscles, tendons or other soft tissues). HO typically occurs after a severe …