The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp
(WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular …

G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to
respond to specific cues in their environment. However, the relationship between stimulus …

SUMMARY A cascade of three protein kinases known as a mitogen-activated protein kinase
(MAPK) cascade is commonly found as part of the signaling pathways in eukaryotic cells …

▪ Abstract Guanine nucleotide binding (G) proteins relay extracellular signals encoded in
light, small molecules, peptides, and proteins to activate or inhibit intracellular enzymes and …

G protein βγ subunits are central participants in G protein-coupled receptor signaling
pathways. They interact with receptors, G protein α subunits and downstream targets to …

Genome-wide transcript profiling was used to monitor signal transduction during yeast
pheromone response. Genetic manipulations allowed analysis of changes in gene …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

Diploid Saccharomyces cerevisiae strains starved for nitrogen undergo a developmental
transition from a colonial form of growth to a filamentous pseudohyphal form. This …

Mutation in the Silencing Gene SIR4 Can Delay Aging in S. cerevisiae Page 1 Cell, Vol. 80,
485-496, February 10, 1995, Copyright © 1995 by Cell Press Mutation in the Silencing Gene …