The review describes the stability and the coordination modes of Cu2+ complexes with
different regions of N-terminus prion proteins. The structural features of the different metal …

Silent information regulator 2-related enzyme 1 (SIRT1), a protein deacetylase, is known to
strongly protect cells against oxidative stress-induced injury. The nuclear factor E2-related …

Although initially disregarded compared to prion pathogenesis, the functions exerted by the
cellular prion protein PrP C have gained much interest over the past two decades. Research …

We reported earlier that reactive oxygen species are implicated in necrotic injury induced by
a transient exposure of cultured renal tubular cells to a high concentration of cisplatin but not …

The normal prion protein is abundantly expressed in the central nervous system, but its
biological function remains unclear. The prion protein has octapeptide repeat regions that …

The prion protein (PrP) is highly conserved and ubiquitously expressed, suggesting that it
plays an important physiological function. However, despite decades of investigation, this …

Malignant gliomas are the most common and lethal primary central nervous system
neoplasms. Several intriguing lines of evidence have recently emerged indicating that the …

The PrPC protein, which is especially present in the cellular membrane of nervous system
cells, has been extensively studied for its controversial antioxidant activity. In this study, we …

Our earlier studies showed the inhibitory effects of cadmium (Cd) and paraquat (PQ) on the
gene expression of DNA mismatch recognition proteins in zebrafish (Danio rerio) embryos …

Paraquat (PQ), a commonly used herbicide, is highly toxic to humans and animals. The
primary injury occurs in the lung, where PQ is actively taken up by alveolar epithelial cells …