Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules
between the informational level of nucleic acids and the functional level of proteins. They …

The numerous post-transcriptional modifications of tRNA play a crucial role in tRNA function.
While most modifications are introduced to tRNA independently, several sets of …

Motivation Dihydrouridine (D) is a common RNA post-transcriptional modification found in
eukaryotes, bacteria and a few archaea. The modification can promote the conformational …

Prominent in the L-shaped three-dimensional structure of tRNAs is the “elbow” where their
two orthogonal helical stacks meet. It has a conserved structure arising from the interaction …

Until recently, post-transcriptional modifications of RNA were largely restricted to noncoding
RNA species. However, this belief seems to have quickly dissipated with the growing …

Impaired metabolism may play an important role in the pathogenesis of lethal prostate
cancer, yet there is a paucity of evidence regarding the association. We conducted a large …

The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine
by the Dus family of NADPH-dependent reductases and is typically found within the eponym …

To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes
have been identified not only in thermophiles but also in mesophiles. Because most …

Dihydrouridine (D), a prevalent and evolutionarily conserved base in the transcriptome,
primarily resides in tRNAs and, to a lesser extent, in mRNAs. Notably, this modification is …

Dihydrouridine (D) is a common modified base found predominantly in transfer RNA (tRNA).
Despite its prevalence, the mechanisms underlying dihydrouridine biosynthesis, particularly …