Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

We present a high-quality de novo genome assembly (rheMacS) of the Chinese rhesus
macaque (Macaca mulatta) using long-read sequencing and multiplatform scaffolding …

Depolarizing sodium (Na+) leak currents carried by the NALCN channel regulate the resting
membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion …

Persistently depolarizing sodium (Na+) leak currents enhance electrical excitability,. The ion
channel responsible for the major background Na+ conductance in neurons is the Na+ leak …

Paroxysmal movement disorders (PMDs) are rare neurological diseases typically
manifesting with intermittent attacks of abnormal involuntary movements. Two main …

NALCN, a sodium leak channel expressed mainly in the central nervous system, is
responsible for the resting Na+ permeability that controls neuronal excitability. Dysfunctions …

During morphogenesis, cells communicate with each other to shape tissues and organs.
Several lines of recent evidence indicate that ion channels play a key role in cellular …

NALCN regulates the resting membrane potential by mediating the Na+ leak current in
neurons, and it functions as a channelosome in complex with FAM155A, UNC79, and …

The sodium-leak channel NALCN forms a subthreshold sodium conductance that controls
the resting membrane potentials of neurons. The auxiliary subunits of the channel and their …