[HTML][HTML] The multifaceted role of ferroptosis in liver disease
Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …
[HTML][HTML] Liver fibrosis: mechanistic concepts and therapeutic perspectives
N Roehlen, E Crouchet, TF Baumert - Cells, 2020 - mdpi.com
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
[HTML][HTML] ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis
Background & Aims Hepatocellular carcinoma (HCC), a leading cause of cancer-related
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …
[HTML][HTML] Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment
KM Schneider, A Mohs, W Gui, EJC Galvez… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
R Singh, A Letai, K Sarosiek - Nature reviews Molecular cell biology, 2019 - nature.com
The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …
treatment outcomes of many human disorders, including neurological and infectious …
Drug-induced liver injury
RJ Andrade, N Chalasani, ES Björnsson… - Nature Reviews …, 2019 - nature.com
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …
occurs either as a predictable event when an individual is exposed to toxic doses of some …
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …
parenchymal injury, persistent activation of inflammatory response as well as sustained …
[HTML][HTML] Cell death in liver diseases: a review
Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
Mechanisms of fibrosis development in nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
Triggering and resolution of inflammation in NASH
S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …