The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular
metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide …

Background Fluoride, an environmental contaminant, is ubiquitously present in air, water,
and soil. It usually enters the body through drinking water and may cause structural and …

The mitochondrial electron transport chain (mtETC) requires mainly coenzyme Q10
(CoQ10), copper (Cu 2+), calcium (Ca 2+), and iron (Fe 2+) ions for efficient ATP production …

The leading first‐in‐class ruthenium‐complex BOLD‐100 currently undergoes clinical phase‐
II anticancer evaluation. Recently, BOLD‐100 is identified as anti‐Warburg compound. The …

In Tibetans, noncoding alleles in EPAS1—whose protein product hypoxia-inducible factor
2α (HIF-2α) drives the response to hypoxia—carry strong signatures of positive selection; …

The terminal electron acceptor of most aerobic respiratory chains, cytochrome c oxidase
(COX), has been highly conserved throughout evolution, from aerobic prokaryotes to …

Estimating the time since death (post mortem interval, PMI) represents one of the most
important tasks in daily forensic casework. For decades, forensic scientists have investigated …

Drug-induced liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver
transplantation in the Western world. Acetaminophen (APAP) overdose is a main contributor …

Oxidative Phosphorylation (OXPHOS) defects can cause severe encephalopathies and no
effective treatment exists for these disorders. To assess the ability of gene replacement to …