Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

AJ Abadi, S Mirzaei, MK Mahabady… - Phytotherapy …, 2022 - Wiley Online Library
Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …

Cisplatin mouse models: treatment, toxicity and translatability

M Perše - Biomedicines, 2021 - mdpi.com
Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide
range of pediatric and adult malignances. However, it has various side effects which limit its …

Cisplatin-induced gastrointestinal toxicity: An update on possible mechanisms and on available gastroprotective strategies

F Shahid, Z Farooqui, F Khan - European Journal of Pharmacology, 2018 - Elsevier
Abstract Cisplatin (cis-diamminedichloroplatinum [II], CP) is most widely prescribed in
chemotherapy and efficaciously treats diverse human cancers, with remission rates> 90% in …

Mechanisms of chemotherapy-induced neurotoxicity

H Was, A Borkowska, A Bagues, L Tu… - Frontiers in …, 2022 - frontiersin.org
Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

GDF15 induces an aversive visceral malaise state that drives anorexia and weight loss

T Borner, HS Wald, MY Ghidewon, B Zhang, Z Wu… - Cell Reports, 2020 - cell.com
The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are
attracting considerable attention for treating obesity. Current experiments in rats investigate …

Revisiting the physiology of nausea and vomiting—challenging the paradigm

RJ Wickham - Supportive care in cancer, 2020 - Springer
Purpose The predominant neurotransmitters and receptors for acute and delayed
chemotherapy-induced nausea and vomiting (CINV) are represented in the current …

Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5‐fluorouracil

RM McQuade, V Stojanovska, E Donald… - …, 2016 - Wiley Online Library
Background The use of the anticancer chemotherapeutic agent 5‐fluorouracil (5‐FU) is often
limited by nausea, vomiting, constipation, and diarrhea; these side‐effects persist long after …

Cannabinoid pharmacology and therapy in gut disorders

JA Uranga, G Vera, R Abalo - Biochemical Pharmacology, 2018 - Elsevier
Cannabis sp. and their products (marijuana, hashish…), in addition to their recreational,
industrial and other uses, have a long history for their use as a remedy for symptoms related …

Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy

G Vera, PA Cabezos, MI Martín, R Abalo - Pharmacology Biochemistry and …, 2013 - Elsevier
Clinical use of antineoplastic drugs is associated with the development of numerous
adverse effects that many patients find intolerable, including peripheral neuropathy …

Dietetic management in gastrointestinal complications from antimalignant chemotherapy

LC Lima, EM Andrade, M Geller, RS Batista, AP Gomes - 2012 - ninho.inca.gov.br
Antineoplastic chemotherapy (CT) represents the sys temic treatment of malignant tumors. It
can be used alone or combined with surgery and/or radiotherapy. The cytotoxic agents used …