Chemokines and their receptors are involved in the pathogenesis of diseases ranging from
asthma to AIDS. Chemokine receptors are G-protein-coupled serpentine receptors that …

The chemokine system coordinates leukocyte migration in immunity and inflammation and is
implicated in the pathogenesis of many human diseases. Although several successful …

Background Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic
hematopoietic stem-cell transplantation (HSCT). The chemokine receptor CCR5 appears to …

Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), an inhibitor of inosine-
5′-monophosphate dehydrogenase, has several immunosuppressant actions. MPA …

Chemokines and chemokine receptors are involved in the resolution or progression of renal
disease. Locally secreted chemokines mediate leukocyte recruitment during the initiation …

Chemokine receptors are found on cell surfaces and promote cellular migration by
chemotaxis. The CC chemokine receptor 5 (CCR5) is used by the human immunodeficiency …

The need for new classes of antiretroviral drugs has become apparent because of
increasing concern about the long-term toxic effects of existing drugs, the need to combat …

Homozygous carriers of CCR5-Δ32, a gene variant of CC-type chemokine receptor 5
(CCR5), are highly resistant to infections with human immunodeficiency virus type 1 (HIV-1) …

The expression of chemokines and their receptors is thought to contribute to leukocyte
infiltration and progressive renal fibrosis after unilateral ureter obstruction (UUO). We …

The pharmaceutical industry has targeted various types of molecules to subdue
inflammatory diseases. Drugs that disrupt cell migration appear particularly promising in …