Until recently, inflammatory chemokines were viewed mainly as indispensable “gate
keepers” of immunity and inflammation. However, updated research indicates that cancer …

Multiple myeloma (MM) is typically exemplified by a desynchronized cytokine system with
increased levels of inflammatory cytokines. We focused on the contrast between …

Neuroinflammation plays an important role in the progression of Parkinson's disease (PD)
and hence may represent a target for treatment. The drugs used currently for PD only …

Multiple myeloma (MM) cells specifically attract peripheral-blood monocytes, while
interaction of MM with bone marrow stromal cells (BMSCs) significantly increased monocyte …

Background We assessed the mechanism by which multiple myeloma (MM) shapes the
bone marrow (BM) microenvironment and affects MΦ polarization. Methods In vivo xenograft …

Elevated levels of plasmacytoid dendritic cells (pDC) have been reported in breast cancer
patients, but the significance remains undefined. Using three immunocompetent mouse …

Abstract Interleukin‐16 (IL‐16) is generated as a precursor molecule that is cleaved by
caspase‐3 to produce a pro‐IL‐16 molecule that functions as a regulator of T cell growth …

Abstract Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and …

Despite improved outcomes in multiple myeloma (MM), a cure remains elusive. However,
even before the current therapeutic era, 5% of patients survived> 10 years and we propose …

The selective loss of dopaminergic neurons in Parkinson's disease (PD) is associated with
microglial activation. Therefore, the importance of early therapeutic intervention to inhibit …