In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …

Insulin receptors (IRs) and insulin signaling proteins are widely distributed throughout the
central nervous system (CNS). To study the physiological role of insulin signaling in the …

Obesity develops when energy intake exceeds energy expenditure over time. Numerous
neurotransmitters, hormones, and factors have been implicated to coordinately control …

Nutritional Biochemistry takes a scientific approach to nutrition. It covers not just" whats"--
nutritional requirements--but why they are required for human health, by describing their …

To investigate the dependence of LH pulsatility on energy availability (dietary energy intake
minus exercise energy expenditure), we measured LH pulsatility after manipulating the …

Circulating insulin inhibits endogenous glucose production. Here we report that bidirectional
changes in hypothalamic insulin signaling affect glucose production. The infusion of either …

Internal physiological states influence behavioral decisions. We have investigated the
underlying cellular and molecular mechanisms at the first olfactory synapse for starvation …

Feeding behavior is critical for survival. In addition to providing all of the body's
macronutrients (carbohydrates, lipids, and proteins) and most micronutrients (minerals and …

The hypothesis that leptin (OB protein) acts in the hypothalamus to reduce food intake and
body weight is based primarily on evidence from leptin-deficient, ob/ob mice. To investigate …