The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Abstract Noonan syndrome [NS; Mendelian Inheritance in Men (MIM)# 163950] and related
syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD …

Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been …

Nonalcoholic steatohepatitis (NASH) is triggered by hepatocyte death through activation of
caspase 6, as a result of decreased adenosine monophosphate (AMP)-activated protein …

The alternative activation of M2 macrophages in the lungs has been implicated as a
causative agent in pulmonary fibrosis; however, the mechanisms underlying M2 polarization …

RASopathies are developmental disorders caused by germline mutations in the Ras-MAPK
pathway, and are characterized by a broad spectrum of functional and morphological …

There is a constant need for new therapeutic compounds. Fungi have proven to be an
excellent, but underexplored source for biologically active compounds with therapeutic …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease with dismal
prognosis and no cure. The potential role of the ubiquitously expressed SH2 domain …

Congenital heart disease is the most common human developmental disorder, affecting∼ 1:
100 newborns, and is the primary cause of birth-defect related deaths worldwide. As a major …

Noonan syndrome (NS) is a common autosomal dominant disorder that presents with short
stature, craniofacial dysmorphism, and cardiac abnormalities. Activating mutations in the …