[HTML][HTML] Spindle assembly checkpoint activation and silencing at kinetochores
The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …
Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action
Globally, breast cancer is the most common cancer type and is one of the most significant
causes of deaths in women. To date, multiple clinical interventions have been applied …
causes of deaths in women. To date, multiple clinical interventions have been applied …
An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis
G Lu, Y Xu, Q Liu, M Chen, H Sun, P Wang, X Li… - Nature …, 2022 - nature.com
Limited stem cells, poor stretchability and mismatched interface fusion have plagued the
reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable …
reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable …
The involvement of ubiquitination machinery in cell cycle regulation and cancer progression
T Zou, Z Lin - International Journal of Molecular Sciences, 2021 - mdpi.com
The cell cycle is a collection of events by which cellular components such as genetic
materials and cytoplasmic components are accurately divided into two daughter cells. The …
materials and cytoplasmic components are accurately divided into two daughter cells. The …
CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
Open (O) and closed (C) topologies of HORMA-domain proteins are respectively associated
with inactive and active states of fundamental cellular pathways. The HORMA protein O …
with inactive and active states of fundamental cellular pathways. The HORMA protein O …
Biology of the Caenorhabditis elegans Germline Stem Cell System
EJ Albert Hubbard, T Schedl - Genetics, 2019 - academic.oup.com
Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …
system is essential for animal reproduction, controlling both the timing and number of …
Evolutionary dynamics and molecular mechanisms of HORMA domain protein signaling
Controlled assembly and disassembly of multi-protein complexes is central to cellular
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …
A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores
During cell division, kinetochores couple chromosomes to spindle microtubules. To protect
against chromosome gain or loss, kinetochores lacking microtubule attachment locally …
against chromosome gain or loss, kinetochores lacking microtubule attachment locally …
APC/C ubiquitin ligase: functions and mechanisms in tumorigenesis
MS Schrock, BR Stromberg, L Scarberry… - Seminars in cancer …, 2020 - Elsevier
The anaphase promoting complex/cyclosome (APC/C), is an evolutionarily conserved
protein complex essential for cellular division due to its role in regulating the mitotic …
protein complex essential for cellular division due to its role in regulating the mitotic …
Ubiquitin-proteasome system–regulated protein degradation in spermatogenesis
Y Xiong, C Yu, Q Zhang - Cells, 2022 - mdpi.com
Spermatogenesis is a prolonged and highly ordered physiological process that produces
haploid male germ cells through more than 40 steps and experiences dramatic …
haploid male germ cells through more than 40 steps and experiences dramatic …