The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

Beyond an eminent role in hemostasis and thrombosis, platelets are characterized by expert
functions in assisting and modulating inflammatory reactions and immune responses. This is …

We studied whether circulating activated platelets and platelet–leukocyte aggregates cause
the development of atherosclerotic lesions in apolipoprotein-E–deficient (Apoe−/−) mice …

Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can
cause a range of diseases from self-limiting dengue fever to life-threatening dengue …

Background—Circulating platelets and chemoattractant proteins, such as the CC chemokine
RANTES, contribute to the activation and interaction of monocytes and endothelium and …

Objective—Platelet activation mediates multiple cellular responses, including secretion of
chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs). We …

P-selectin is an adhesion molecule expressed on activated platelets and endothelium. It is
known to play an important role in atherosclerosis. P-selectin also circulates in plasma in a …

Platelets, monocytes, and endothelial cells are instrumental in the development and
progression of cardiovascular diseases. Inflammation, a key process underlying …

Background Systemic administration of linear polyethylenimine–DNA complexes (L-
PEI/DNA) results in transient expression of the transgene in the lung. This study analyzes …

Background—Present therapies for acute coronary syndromes aim toward limiting platelet–
platelet adhesion and aggregation processes. However, platelet–leukocyte interactions may …