Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …

The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …

INTRODUCTION Depression is an episodic form of mental illness, yet the circuit-level
mechanisms driving the induction, remission, and recurrence of depressive episodes over …

It is assumed that synaptic strengthening and weakening balance throughout learning to
avoid runaway potentiation and memory interference. However, energetic and informational …

Dendritic spines are the major loci of synaptic plasticity and are considered as possible
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …

Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

Learning induces the formation of new excitatory synapses in the form of dendritic spines,
but their functional properties remain unknown. Here, using longitudinal in vivo two-photon …

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for
information processing in neural circuits. However, little is known about the spatial principles …

Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …