Synaptic plasticity forms and functions
JC Magee, C Grienberger - Annual review of neuroscience, 2020 - annualreviews.org
Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …
been considered an important component of learning and memory. Computational and …
[HTML][HTML] Shaping neuronal fate: functional heterogeneity of direct microglia-neuron interactions
The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …
and neurological disorders is increasingly recognized. However, until recently, the nature of …
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
INTRODUCTION Depression is an episodic form of mental illness, yet the circuit-level
mechanisms driving the induction, remission, and recurrence of depressive episodes over …
mechanisms driving the induction, remission, and recurrence of depressive episodes over …
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
It is assumed that synaptic strengthening and weakening balance throughout learning to
avoid runaway potentiation and memory interference. However, energetic and informational …
avoid runaway potentiation and memory interference. However, energetic and informational …
Labelling and optical erasure of synaptic memory traces in the motor cortex
A Hayashi-Takagi, S Yagishita, M Nakamura, F Shirai… - Nature, 2015 - nature.com
Dendritic spines are the major loci of synaptic plasticity and are considered as possible
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …
Dendritic integration: 60 years of progress
GJ Stuart, N Spruston - Nature neuroscience, 2015 - nature.com
Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …
receive is critical to understanding how the brain works. Modeling studies in silico and …
Learning binds new inputs into functional synaptic clusters via spinogenesis
Learning induces the formation of new excitatory synapses in the form of dendritic spines,
but their functional properties remain unknown. Here, using longitudinal in vivo two-photon …
but their functional properties remain unknown. Here, using longitudinal in vivo two-photon …
Dendritic spines: the locus of structural and functional plasticity
C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …
changed dramatically the rate of progress towards the understanding of the complex …
Whole-neuron synaptic mapping reveals spatially precise excitatory/inhibitory balance limiting dendritic and somatic spiking
The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for
information processing in neural circuits. However, little is known about the spatial principles …
information processing in neural circuits. However, little is known about the spatial principles …
Toward a neurocentric view of learning
Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …
learning. Recent optogenetic studies on memory engram formation assign a critical role in …