Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

The concept of the antibiotic resistome was introduced just over a decade ago, and since
then, active resistome studies have been conducted. In the present study, we describe the …

The unique genetic makeup and remarkable competency of Vibrio cholerae are the key
factors that help the cholera pathogen adapt rapidly to adverse environmental conditions …

The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …

Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed
interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis …

Rifamycins are a class of antibiotics that were first discovered in 1957 and are known for
their use in treating tuberculosis (TB). Rifamycins exhibit bactericidal activity against many …

Highlights•Adjuvants potentiate existing antibiotics or combat mechanisms of
resistance.•Probes enable the identification of enzymes that modify tuberculosis …

Sulfonamide-degrading bacteria have been discovered in various environments, suggesting
the presence of novel resistance mechanisms via drug inactivation. In this study …

The history of antibiotic use in the clinic is one of initial efficacy followed inevitably by the
emergence of resistance. Often this resistance is the result of the capture and mobilization of …

Conspectus Rifamycin antibiotics include the WHO essential medicines rifampin, rifabutin,
and rifapentine. These are semisynthetic derivatives of the natural product rifamycins …