One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Abstract The Diels–Alder reaction is one of the most powerful and widely used methods in
synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the …

Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …

New enzyme catalysts are usually engineered by repurposing the active sites of natural
proteins. Here we show that design and directed evolution can be used to transform a non …

Diels–Alder reactions are among the most powerful synthetic transformations to construct
complex natural products. Despite that increasing of enzymatic intramolecular Diels–Alder …

With the widespread use of immunosuppressive agents and the increase in patients with
severe infections, the incidence of fungal infections worldwide has increased year by year …

More than 60% of pharmaceuticals are related to natural products (NPs), chemicals
produced by living organisms. Despite this, the rate of NP discovery has slowed over the …

Bioorthogonal click chemistry—employing antibody-conjugated trans-cyclooctenes (TCO)
and tetrazine (Tz)-based radioligands able to covalently bind in vivo—appeared recently as …

Compared with the conventional Diels–Alder reaction, the development of selective cross-
Diels–Alder reactions between two different conjugated dienes, especially in a catalytic …