[HTML][HTML] Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment
H Harjunpää, M Llort Asens, C Guenther… - Frontiers in …, 2019 - frontiersin.org
The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …
playing a dual role in tumor development. The effector cells of the immune system can …
Immune-checkpoint inhibitor use in patients with cancer and pre-existing autoimmune diseases
Immune-checkpoint inhibitors (ICIs) have dramatically changed the management of
advanced cancers. Designed to enhance the antitumour immune response, they can also …
advanced cancers. Designed to enhance the antitumour immune response, they can also …
[HTML][HTML] Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
Therapeutic blocking of the PD1 pathway results in significant tumor responses, but
resistance is common. We demonstrate that prolonged interferon signaling orchestrates …
resistance is common. We demonstrate that prolonged interferon signaling orchestrates …
[HTML][HTML] Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)
P Danaher, S Warren, R Lu, J Samayoa… - … for immunotherapy of …, 2018 - Springer
Abstract The Tumor Inflammation Signature (TIS) is an investigational use only (IUO) 18-
gene signature that measures a pre-existing but suppressed adaptive immune response …
gene signature that measures a pre-existing but suppressed adaptive immune response …
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti–PD-1 therapy
Purpose: Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic
cancer therapies. Identifying factors predicting clinical response could guide patient …
cancer therapies. Identifying factors predicting clinical response could guide patient …
New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape
Highlights•Genomics analyses to identify the targets of cancer immunoediting and design
personalized cancer immunotherapy.•Emerging role of innate immune cells (NK, DC …
personalized cancer immunotherapy.•Emerging role of innate immune cells (NK, DC …
[HTML][HTML] Oncology meets immunology: the cancer-immunity cycle
The genetic and cellular alterations that define cancer provide the immune system with the
means to generate T cell responses that recognize and eradicate cancer cells. However …
means to generate T cell responses that recognize and eradicate cancer cells. However …
Epithelial–mesenchymal transition is associated with a distinct tumor microenvironment including elevation of inflammatory signals and multiple immune checkpoints …
Y Lou, L Diao, ERP Cuentas, WL Denning, L Chen… - Clinical Cancer …, 2016 - AACR
Purpose: Promising results in the treatment of non–small cell lung cancer (NSCLC) have
been seen with agents targeting immune checkpoints, such as programmed cell death 1 (PD …
been seen with agents targeting immune checkpoints, such as programmed cell death 1 (PD …
[HTML][HTML] Tumor microenvironment: a metabolic player that shapes the immune response
S Cassim, J Pouyssegur - International journal of molecular sciences, 2019 - mdpi.com
Immune cells survey and patrol throughout the body and sometimes take residence in niche
environments with distinct cellular subtypes and nutrients that may fluctuate from those in …
environments with distinct cellular subtypes and nutrients that may fluctuate from those in …
Safety and efficacy of immune checkpoint inhibitors in patients with cancer and preexisting autoimmune disease: a nationwide, multicenter cohort study
A Tison, G Quéré, L Misery… - Arthritis & …, 2019 - Wiley Online Library
Objective Immune checkpoint inhibitors (ICI s) for cancer therapy frequently induce immune‐
related adverse effects (IRAE s). Therefore, most patients with preexisting autoimmune …
related adverse effects (IRAE s). Therefore, most patients with preexisting autoimmune …