Research Review: A guide to computing and implementing polygenic scores in developmental research
AG Allegrini, JR Baldwin, W Barkhuizen… - Journal of Child …, 2022 - Wiley Online Library
The increasing availability of genotype data in longitudinal population‐and family‐based
samples provides opportunities for using polygenic scores (PGS) to study developmental …
samples provides opportunities for using polygenic scores (PGS) to study developmental …
Participation bias in the UK Biobank distorts genetic associations and downstream analyses
While volunteer-based studies such as the UK Biobank have become the cornerstone of
genetic epidemiology, the participating individuals are rarely representative of their target …
genetic epidemiology, the participating individuals are rarely representative of their target …
Polygenic scoring accuracy varies across the genetic ancestry continuum
Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …
example, by genetic ancestries and/or social determinants of health), preventing their …
Polygenic basis and biomedical consequences of telomere length variation
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …
health disparities. We propose PolyPred, a method that improves cross-population …
Polygenic scores in psychiatry: on the road from discovery to implementation
The hypothesis that multiple genetic variants contribute to psychiatric disorders was first
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
Abstract Background Polygenic scores (PGSs), which assess the genetic risk of individuals
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
The construction of cross-population polygenic risk scores using transfer learning
As most existing genome-wide association studies (GWASs) were conducted in European-
ancestry cohorts, and as the existing polygenic risk score (PRS) models have limited …
ancestry cohorts, and as the existing polygenic risk score (PRS) models have limited …
Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
We develop a method, SBayesRC, that integrates genome-wide association study (GWAS)
summary statistics with functional genomic annotations to improve polygenic prediction of …
summary statistics with functional genomic annotations to improve polygenic prediction of …