Overview of therapeutic drug monitoring and clinical practice

Z Fang, H Zhang, J Guo, J Guo - Talanta, 2024 - Elsevier
With the rapid development of clinical pharmacy in China, therapeutic drug monitoring
(TDM) has become an essential tool for guiding rational clinical drug use and is widely …

Recent advances in quenchbody, a fluorescent immunosensor

J Dong, H Ueda - Sensors, 2021 - mdpi.com
The detection of viruses, disease biomarkers, physiologically active substances, drugs, and
chemicals is of great significance in many areas of our lives. Immunodetection technology is …

Design of an antigen-triggered nanobody-based fluorescence probe for pet immunoassay to detect quinalphos in food samples

YF Liang, JD Li, RY Fang, ZL Xu, L Luo… - Analytical …, 2023 - ACS Publications
Photoinduced electron-transfer (PET) immunoassay based on a fluorescence site-
specifically labeled nanobody, also called mini Quenchbody (Q-body), exhibits extraordinary …

Creation of a nanobody-based fluorescent immunosensor mini Q-body for rapid signal-on detection of small hapten methotrexate

A Inoue, Y Ohmuro-Matsuyama, T Kitaguchi… - ACS …, 2020 - ACS Publications
“Quenchbody (Q-body)” is a quench-based fluorescent biosensor labeled with a fluorescent
dye near the antigen-binding site of an antibody. Q-bodies can detect a range of target …

Rapid and sensitive SARS-CoV-2 detection using a homogeneous fluorescent immunosensor Quenchbody with crowding agents

B Zhu, N Nosaka, S Kanamaru, J Dong, Y Dai, A Inoue… - Analyst, 2022 - pubs.rsc.org
Antigen tests for SARS-CoV-2 are widely used by the public during the ongoing COVID-19
pandemic, which demonstrates the societal impact of homogeneous immunosensor-related …

Application of N-doped carbon quantum dots as a resonance light scattering probe for determination of fluvoxamine

F Fazl, MB Gholivand - Journal of Photochemistry and Photobiology A …, 2024 - Elsevier
Resonance light scattering (RLS) as a simple, rapid, inexpensive method was introduced for
the determination of fluvoxamine in real samples (blood serum and commercial tablet) …

Secondary structure and conformational stability of the antigen residues making contact with antibodies

X Qiao, L Qu, Y Guo, T Hoshino - The Journal of Physical …, 2021 - ACS Publications
Antibodies are crucial biomolecules that bring high therapeutic efficacy in medicine and
accurate molecular detection in diagnosis. Many studies have been devoted to analyzing …

PM Q-probe: A fluorescent binding protein that converts many antibodies to a fluorescent biosensor

J Dong, C Miyake, T Yasuda, H Oyama, I Morita… - Biosensors and …, 2020 - Elsevier
Quenchbody (Q-body) is a fluorescent biosensor in which a fluorescent dye is tagged near
the antigen binding site of an antibody. The fluorescence of the dye is quenched by the …

Quenchbodies That Enable One-Pot Detection of Antigens: A Structural Perspective

HJ Jeong - Bioengineering, 2023 - mdpi.com
Quenchbody (Q-body) is a unique, reagentless, fluorescent antibody whose fluorescent
intensity increases in an antigen-concentration-dependent manner. Q-body-based …

Development of a spacer-optimized quenchbody against tumor necrosis factor alpha

H Yun, H Ueda, HJ Jeong - Biotechnology and Bioprocess Engineering, 2022 - Springer
Tumor necrosis factor alpha (TNFα) is a proinflammatory cytokine, and its overproduction
causes infectious diseases and autoimmune disorders. Therefore, rapid and accurate …