Are sirtuins viable targets for improving healthspan and lifespan?
Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of developing many diseases increases exponentially with old age …
medicine, the risk of developing many diseases increases exponentially with old age …
[HTML][HTML] The sirtuin family's role in aging and age-associated pathologies
The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …
Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review
RA Watkins, C Evans-Molina, JS Blum… - Translational …, 2014 - Elsevier
Type 1 diabetes (T1D) is an autoimmune disease with a prolonged and variable latent
period that culminates in the destruction of pancreatic β-cells and the development of …
period that culminates in the destruction of pancreatic β-cells and the development of …
[HTML][HTML] Identification of a SIRT1 mutation in a family with type 1 diabetes
A Biason-Lauber, M Böni-Schnetzler, BP Hubbard… - Cell metabolism, 2013 - cell.com
Type 1 diabetes is caused by autoimmune-mediated β cell destruction leading to insulin
deficiency. The histone deacetylase SIRT1 plays an essential role in modulating several age …
deficiency. The histone deacetylase SIRT1 plays an essential role in modulating several age …
[HTML][HTML] Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice
N Wang, X Tian, Y Chen, H Tan, P Xie, S Chen, Y Fu… - Scientific reports, 2017 - nature.com
The aim of this study was to determine whether low dose doxycycline as an anti-
inflammatory agent could improve glucose metabolism in diabetic animals. Therefore …
inflammatory agent could improve glucose metabolism in diabetic animals. Therefore …
Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: the role of hydrogen sulfide
Background Protein malnutrition in childhood predisposes individuals to vascular and
pancreatic endocrine dysfunction, thus increasing the risk of diabetes and hypertension …
pancreatic endocrine dysfunction, thus increasing the risk of diabetes and hypertension …
Variants in the SIRT1 Gene May Affect Diabetes Risk in Interaction With Prenatal Exposure to Famine
IPG Botden, MC Zillikens, SR De Rooij… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE To investigate whether SIRT1, a nutrient-sensing histone deacetylase,
influences fetal programming during malnutrition. RESEARCH DESIGN AND METHODS In …
influences fetal programming during malnutrition. RESEARCH DESIGN AND METHODS In …
Targeted gene delivery: importance of administration routes
S Fumoto, S Kawakami, M Hashida… - Novel gene therapy …, 2013 - books.google.com
Genetherapyisapromisingapproachtotreatin… refractory diseasesat thegenetic level.
Basically, in gene therapy, targetgeneexpressionisinducedby deliveringforeigngenes …
Basically, in gene therapy, targetgeneexpressionisinducedby deliveringforeigngenes …
Gene delivery in tissue engineering and regenerative medicine
YL Fang, XG Chen, G WT - Journal of Biomedical Materials …, 2015 - Wiley Online Library
As a promising strategy to aid or replace tissue/organ transplantation, gene delivery has
been used for regenerative medicine applications to create or restore normal function at the …
been used for regenerative medicine applications to create or restore normal function at the …
WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
OBJECTIVE WldS (Wallerian degeneration slow), a fusion protein from a spontaneous
mutation containing full-length nicotinamide mononucleotide adenylyltransferase 1, has …
mutation containing full-length nicotinamide mononucleotide adenylyltransferase 1, has …