[HTML][HTML] Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a
S Gründer, X Chen - International journal of physiology …, 2010 - ncbi.nlm.nih.gov
Acid-sensing ion channels (ASICs) are H+-gated Na+ channels, which are present in most, if
not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the …
not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the …
Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes
I Baconguis, E Gouaux - Nature, 2012 - nature.com
Acid-sensing ion channels (ASICs) are voltage-independent, amiloride-sensitive channels
involved in diverse physiological processes ranging from nociception to taste. Despite the …
involved in diverse physiological processes ranging from nociception to taste. Despite the …
Acid-sensing ion channels: trafficking and synaptic function
X Zha - Molecular brain, 2013 - Springer
Extracellular acidification occurs in the brain with elevated neural activity, increased
metabolism, and neuronal injury. This reduction in pH can have profound effects on brain …
metabolism, and neuronal injury. This reduction in pH can have profound effects on brain …
Acid-sensing ion channel 3: An analgesic target
Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …
Structure and activity of the acid-sensing ion channels
TW Sherwood, EN Frey… - American Journal of …, 2012 - journals.physiology.org
The acid-sensing ion channels (ASICs) are a family of proton-sensing channels expressed
throughout the nervous system. Their activity is linked to a variety of complex behaviors …
throughout the nervous system. Their activity is linked to a variety of complex behaviors …
Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?
Ischemic brain injury results from complicated cellular mechanisms. The present therapy for
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
Modulation of acid-sensing ion channel activity by nitric oxide
Acid-sensing ion channels (ASICs) are a class of ion channels activated by extracellular
protons and are believed to mediate the pain caused by tissue acidosis. Although ASICs …
protons and are believed to mediate the pain caused by tissue acidosis. Although ASICs …
Mechanisms of action of the peptide toxins targeting human and rodent acid-sensing ion channels and relevance to their in vivo analgesic effects
Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …
largely expressed in the nervous system of rodents and humans. At least six isoforms …
Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC)
Y Ben-Shahar - Advances in genetics, 2011 - Elsevier
All animals use a sophisticated array of receptor proteins to sense their external and internal
environments. Major advances have been made in recent years in understanding the …
environments. Major advances have been made in recent years in understanding the …
The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila
KM Zelle, B Lu, SC Pyfrom… - G3: Genes, Genomes …, 2013 - academic.oup.com
Degenerin/epithelial sodium channels (DEG/ENaC) represent a large family of animal-
specific membrane proteins. Although the physiological functions of most family members …
specific membrane proteins. Although the physiological functions of most family members …