It is increasingly clear that mechanotransduction pathways play important roles in regulating
fundamental cellular functions. Of the basic mechanical functions, the determination of …

The Hippo-YAP pathway mediates the control of cell proliferation by contact inhibition as
well as other attributes of the physical state of cells in tissues. Several mechanisms sense …

Planar cell polarization entails establishment of cellular asymmetries within the tissue plane.
An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra-and …

The success of peritoneal dialysis (PD) is dependent on the structural and functional
integrity of the peritoneal membrane. The mesothelium lines the peritoneal membrane and …

Compared with neural crest‐derived melanocytes, retinal pigment epithelium (RPE) cells in
the back of the eye are pigment cells of a different kind. They are a part of the brain, form an …

Simple Summary Raf kinase inhibitor protein (RKIP) expression in cancer cells is
significantly reduced and promoting cancer cells growth and invasiveness. Overexpresssion …

Tissue-wide patterning is essential to multicellular development, requiring cells to
individually generate polarity axes and coordinate them in space and time with neighbors …

The exocyst complex plays a critical role in determining both temporal and spatial dynamics
of exocytic vesicle tethering and fusion with the plasma membrane. However, the …

Several bacterial pathogens, including Listeria monocytogenes, Shigella flexneri and
Rickettsia spp., have evolved mechanisms to actively spread within human tissues …

Cell contacts provide spatial cues that polarize early embryos and epithelial cells. The
homophilic adhesion protein E-cadherin is required for contact-induced polarity in many …