This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

cAMP‐mediated signaling pathways regulate a multitude of important biological processes
under both physiological and pathological conditions, including diabetes, heart failure and …

cAMP is a second messenger that is essential for relaying hormonal responses in many
biological processes. The discovery of the cAMP target Epac explained various effects of …

Epac1 and Epac2 are cAMP-dependent guanine-nucleotide-exchange factors for the small
GTPases Rap1 and Rap2, and are known to be important mediators of cAMP signaling. The …

cAMP is well known to regulate exocytosis in various secretory cells, but the precise
mechanism of its action remains unknown. Here, we examine the role of cAMP signaling in …

Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium,
calcium, potassium, and chloride channels and fire action potentials spontaneously …

Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of
cAMP‐regulated guanine nucleotide exchange factors (cAMPGEFs) that mediate protein …

It has now been over 10 years since efforts to completely understand the signalling actions
of cAMP (3′‐5′‐cyclic adenosine monophosphate) led to the discovery of exchange …

In endocrine cells within islets of Langerhans calcium ions couple cell stimulation to
hormone secretion. Since the advent of modern fluorimetry, numerous in vitro studies …

The identification of 2′-O-methyl substituted adenosine-3′, 5′-cyclic monophosphate
(cAMP) analogs that activate the Epac family of cAMP-regulated guanine nucleotide …