Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …

Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …

Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …

The condensation of 5-aminopyrazole with various bielectrophilic moieties results in the
formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The …

Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have
discussed the importance of pyrazoles and their biological activities; however, few have …

In the present study, we used benzimidazolone as a starting material to efficiently synthesize
several hybrid compounds of pyrazole benzimidazolone derivatives by the 1, 3-dipolar …

A route for cyclization reaction of N‐allyl‐N′‐benzylideneacetohydrazide and ethyl 2‐
bromo‐2, 2‐difluoroacetate to synthesize 3‐(1‐acetyl‐3‐phenyl‐4, 5‐dihydro‐1H‐pyrazol‐4 …

Background: Pyrazole and its derivatives are known to exhibit significant biological and
pharmacological activities such as anticancer, anti-inflammatory, antioxidant, antibacterial …

Three category of N 1-phenyl pyrazoline (5a–e), N 1-phenyl-sulfonyl pyrazoline (6a–e), and
pyridine analogs (8a–d) of combretastatin-A4 were synthesized. The structures of …

Cancer is an incredibly diverse and difficult disease to treat, and even after decades of
research there is no definitive cure. Therefore, it is highly crucial to search for novel and new …