The consequences of human adenovirus (HAdV) infections are generally mild. However,
despite the perception that HAdVs are harmless, infections can cause severe disease in …

As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have
been reported from 35 countries, including the USA,. Previous studies have found human …

ABSTRACT BACKGROUND The sudden outbreak of severe acute hepatitis of unknown
aetiology (SAHUA) in the first half of 2022 affected more than 1010 children in 35 countries …

Recombinant adeno-associated virus (rAAV) has emerged as an important gene therapy
vector with many clinical trials currently in progress. Analytical characterization and …

Adeno-associated viruses (AAV) rely on helper viruses to transition from latency to lytic
infection. Some AAV serotypes are secreted in a pre-lytic manner as free or extracellular …

Severe acute hepatitis of unknown etiology in children is under investigation in 35 countries.
Although several potential etiologic agents have been investigated, a clear cause for the …

Gene therapy is a promising therapeutic approach for genetic and acquired diseases
nowadays. Among DNA delivery vectors, recombinant adeno‐associated virus (rAAV) is one …

Discovered as a contaminant of adenovirus stocks in the 1960s, adeno-associated virus
(AAV) is a mono-stranded DNA virus that depends on helper factors to replicate. Even …

Rapid advancements have taken place in gene therapy technology. However, effective
methods for treating aging-or age-related chronic diseases, which are often closely related …

Human gene therapy has advanced from twentieth-century conception to twenty-first-century
reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector …