Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …

Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …

Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …

Clinical pancreatic islet transplantation can be considered one of the safest and least
invasive transplant procedures. Remarkable progress has occurred in both the technical …

Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

OBJECTIVE Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events
(SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D) …

The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in …

Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …