Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD)
with unknown etiology in which gradual fibrotic scarring of the lungs leads to usual interstitial …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …

Epithelial–mesenchymal transition (EMT) plays key roles during lung development and
many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer …

The contribution of epithelial–mesenchymal transition (EMT) to human lung fibrogenesis is
controversial. Here we provide evidence that ZEB1-mediated EMT in human alveolar …

Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung
disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to …

Advances have been made in elucidating causes and mechanisms of EMT, potentially
leading to new treatment options, although contributions of EMT to lung fibrosis in vivo …

Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses.
Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive …

Lung cancer is the most common cancer worldwide. Treatment options for lung cancer
include surgery, radiation therapy, chemotherapy, molecularly targeted therapy including …

Long non-coding RNAs (lncRNAs) have been reported to be involved in various
pathophysiological processes in many diseases. However, the role and mechanism of …