Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully
active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates …

Abstract Zhonglin Mou (Corresponding author) The small phenolic compound salicylic acid
(SA) plays an important regulatory role in multiple physiological processes including plant …

Reprogramming of mRNA translation has a key role in cancer development and drug
resistance. However, the molecular mechanisms that are involved in this process remain …

The isolation of human induced pluripotent stem cells (iPSCs),, offers a new strategy for
modelling human disease. Recent studies have reported the derivation and differentiation of …

Ninety‐four percent of human genes are discontinuous, such that segments expressed as
mRNA are contained within exons and separated by intervening segments, called introns …

The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac
activity with its dysregulation being involved in various heart diseases, such as cardiac …

The generation of cortical projection neurons relies on the coordination of radial migration
with branching. Here, we report that the multisubunit histone acetyltransferase Elongator …

Hundreds of protein factors participate in transcription and its regulation in eukaryotes. Many
of these proteins regulate specific genes by targeting upstream promoter regions, whereas a …

The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-
related progenitors. At the onset of corticogenesis, the first-born progenitors are apical …

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support
cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs …