Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Glycosylation is essential to brain development and function, but prior studies have often
been limited to a single analytical technique and excluded region-and sex-specific analyses …

Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate
multi-step process that requires the acquisition of several cancer cell features, including the …

Mass spectrometry–based glycoproteomics has gone through some incredible
developments over the last few years. Technological advances in glycopeptide enrichment …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Small molecule inhibitors of glycosylation enzymes are valuable tools for dissecting glycan
functions and potential drug candidates. Screening for inhibitors of glycosyltransferases are …

Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development,
emerging evidence indicates that tumor microenvironment-mediated changes in …

O-glycosylation is one of the most abundant and diverse types of post-translational
modifications of proteins. O-glycans modulate the structure, stability, and function of proteins …

Advances in genomics are opening new windows into the biology of schizophrenia. Though
common variants individually have small effects on disease risk, GWAS provide a powerful …