Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in
the mammalian body. This cellular variety impacts the spectrum of responses elicited by the …

Endothelial cells play an obligatory role in regulating local vascular tone and maintaining
homeostasis in vascular biology. Cell metabolism, converting food to energy in organisms, is …

Disturbed flow (d-flow) induces atherosclerosis by regulating gene expression in endothelial
cells (ECs). For further mechanistic understanding, we carried out a single-cell RNA …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer
development and progression. Healthy primary neutrophils present potent cytotoxicity …

During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …

Autophagy is an essential intracellular process for cellular quality control. It enables cell
homeostasis through the selective degradation of harmful protein aggregates and damaged …

Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros
(AGM) region. Studies of model organisms defined intersecting signaling pathways that …

In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise
for the treatment of any ailment that relies on bone marrow or blood transplantation. To …

The first definitive blood cells during embryogenesis are derived from endothelial cells in a
highly conserved process known as endothelial-to-haematopoietic transition (EHT). This …