[HTML][HTML] The IL-1 cytokine family as custodians of barrier immunity

L Matarazzo, YEH Santana, PT Walsh, PG Fallon - Cytokine, 2022 - Elsevier
Abstract The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the
functioning of innate and adaptive immunity and the genesis of inflammation. They are …

Pro-and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease

A Andoh, A Nishida - Journal of Gastroenterology, 2023 - Springer
Abstract Interleukin-33 (IL-33), IL-36, and IL-38 are members of the IL-1 cytokine family. The
expression of each cytokine has been reported to be increased in the inflamed mucosa of …

IL-38 in modulating hyperlipidemia and its related cardiovascular diseases

M Lai, H Peng, X Wu, X Chen, B Wang, X Su - International …, 2022 - Elsevier
Hyperlipidemia is confirmed to be associated with several health problems that include the
combination of diabetes mellitus, obesity, and hypertension, ie, metabolic syndrome …

IL-36 cytokines: their roles in asthma and potential as a therapeutic

H Dong, Y Hao, W Li, W Yang, P Gao - Frontiers in Immunology, 2022 - frontiersin.org
Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three
agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 …

A Narrative Review of Cytokine Networks: Pathophysiological and Therapeutic Implications for Inflammatory Bowel Disease Pathogenesis

M Vebr, R Pomahačová, J Sýkora, J Schwarz - Biomedicines, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a lifelong inflammatory immune mediated disorder,
encompassing Crohn's disease (CD) and ulcerative colitis (UC); however, the cause and …

Modulation of interleukin‐36 based inflammatory feedback loop through the hepatocyte‐derived IL‐36R‐P2X7R axis improves steatosis in alcoholic steatohepatitis

Y Shang, HX Yang, X Li, Y Zhang… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Interleukin‐36 is induced by proinflammatory cytokines and
promotes inflammatory responses, creating an IL‐36‐based inflammation loop. Although …

Increased levels of interleukin-36 in obesity and type 2 diabetes fuel adipose tissue inflammation by inducing its own expression and release by adipocytes and …

G Frühbeck, J Gómez-Ambrosi, B Ramírez… - Frontiers in …, 2022 - frontiersin.org
Interleukin (IL)-36 is a recently described cytokine with well-known functions in the
regulation of multiple inflammatory diseases. Since no data exists on how this cytokine …

[HTML][HTML] Interleukin-36 receptor antagonist stimulation in vitro inhibits peripheral and lung-resident T cell response isolated from patients with ventilator-associated …

T Xin, R Xing, H Jiang, F Jin, M Li - International Immunopharmacology, 2024 - Elsevier
Abstract Interleukin-36 (IL-36) cytokine family members play an immunomodulatory function
to immune cells through IL-36 receptor signaling pathway. However, the regulatory role of IL …

New insights on IL‑36 in intestinal inflammation and colorectal cancer

M Li, W Jiang, Z Wang, Y Lu… - Experimental and …, 2023 - spandidos-publications.com
Abstract Interleukin (IL)‑36 is a member of the IL‑1 superfamily, which includes three
receptor agonists and one antagonist and exhibits a familial feature of inflammatory …

Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19

M Xiao, B Lu, R Ding, X Liu, X Wu, Y Li, X Liu… - Science China Life …, 2022 - Springer
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has become a global public health threat. Here we …