A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a
membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …

Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

Nanopore technologies are being developed for fast and direct sequencing of single DNA
molecules through detection of ionic current modulations as DNA passes through a pore's …

Nanopore sequencing of DNA is a single-molecule technique that may achieve long reads,
low cost and high speed with minimal sample preparation and instrumentation. Here, we …

Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …

The advent of a miniaturized DNA sequencing device with a high-throughput contextual
sequencing capability embodies the next generation of large scale sequencing tools. The …

Label-free nanopore technology for sequencing biopolymers such as DNA and RNA could
potentially replace existing methods if improvements in cost, speed, and accuracy are …

DNA sequencing and hence genomics have been transformed over the last decade by the
commercialization of inexpensive, massively parallel, short-read sequencing technology …

There has been significant progress made in the field of nanopore biosensor development
and sequencing applications, which address previous limitations that restricted widespread …

Precise and efficient mapping of epigenetic markers on DNA may become an important
clinical tool for prediction and identification of ailments. Methylated CpG sites are involved in …