[HTML][HTML] Thiazole ring-the antimicrobial, anti-inflammatory, and anticancer active scaffold
S Hosseininezhad, A Ramazani - Arabian Journal of Chemistry, 2023 - Elsevier
Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …
Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer
EA Abdelsalam, AA Abd El-Hafeez… - Journal of enzyme …, 2022 - Taylor & Francis
New series of thiazolyl-pyrazoline derivatives (7a–7d, 10a–10d and 13a–13f) have been
synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities …
synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities …
[HTML][HTML] Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors
M Hawash - Cells, 2024 - mdpi.com
Protein kinases have essential responsibilities in controlling several cellular processes, and
their abnormal regulation is strongly related to the development of cancer. The …
their abnormal regulation is strongly related to the development of cancer. The …
Curcumin based pyrazole-thiazole hybrids as antiproliferative agents: Synthesis, pharmacokinetic, photophysical properties, and docking studies
A series of new curcumin pyrazole-thiazole hybrids (C 1-C 8) were synthesized and
characterized by fundamental spectral analysis. The synthesized compounds were tested for …
characterized by fundamental spectral analysis. The synthesized compounds were tested for …
[HTML][HTML] Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents
A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and
their chemical structures were confirmed by spectral data (infrared, 1 H & 13 C NMR and …
their chemical structures were confirmed by spectral data (infrared, 1 H & 13 C NMR and …
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
Lung cancer is one of the most common cancer types of cancer with the highest mortality
rates. However, while epidermal growth factor receptor (EGFR) is an important parameter for …
rates. However, while epidermal growth factor receptor (EGFR) is an important parameter for …
New Thiazolyl-Pyrazoline derivatives as potential dual EGFR/HER2 inhibitors: design, synthesis, anticancer activity evaluation and in silico study
A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …
have been designed and synthesized through the combination of thiazole and pyrazoline …
[HTML][HTML] The flavonoid hesperidin methyl chalcone as a potential therapeutic agent for cancer therapy: Molecular docking, in vitro cytotoxicity, and in vivo antitumor …
SMD Rizvi, MP Mudagal, SS Boregowda… - Arabian Journal of …, 2023 - Elsevier
Hesperidin methyl chalcone (HMC) is a methylation product of the flavanone hesperidin, a
flavonoid derived from citrus fruits. Many reports have emphasized the analgesic, anti …
flavonoid derived from citrus fruits. Many reports have emphasized the analgesic, anti …
[PDF][PDF] Theoretical Investigation and Design of Novel Anti-proliferative Agents against Hepatocellular Carcinoma from Benzimidazole-Chalcone derivatives
Hepatocellular carcinoma (HCC) is a liver cancer that arises from abnormal proliferation of
the hepatocytes and accounts for 80% of primary liver cancer cases [1]. HCC is recognized …
the hepatocytes and accounts for 80% of primary liver cancer cases [1]. HCC is recognized …