Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Endothelium‐dependent contractions contribute to endothelial dysfunction in various animal
models of aging, diabetes and cardiovascular diseases. In the spontaneously hypertensive …

Prostanoids are bioactive lipid mediators and take part in many physiological and
pathophysiological processes in practically every organ, tissue and cell, including the …

Aspirin and P2Y12 antagonists are commonly used anti‐platelet agents. Aspirin produces its
effects through inhibition of thromboxane A2 (TXA2) production, while P2Y12 antagonists …

Despite all the advances of modern medicine, atherosclerosis continues to be one of the
most important medical and social problems. Atherosclerosis is the cause of several …

Cardiovascular diseases are the leading cause of global deaths, and many risk factors
contribute to their pathogenesis. In this context, prostanoids, which derive from arachidonic …

Endothelial cells regulate vascular tone by releasing various contracting and relaxing factors
including nitric oxide (NO), arachidonic acid metabolites (derived from cyclooxygenases …