DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Fertilization triggers assembly of higher‐order chromatin structure from a condensed
maternal and a naïve paternal genome to generate a totipotent embryo. Chromatin loops …

The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …

The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular
memory that ensures faithful commitment to transcriptional programs during mammalian …

Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-
methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5 …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is
accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxidation of 5 …

Epigenetics plays an important role in orchestrating key biologic processes. Epigenetic
marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are …