Telomerase and the control of telomere length are intimately linked to the process of
tumourigenesis in humans. Here I review the evidence that variation at the 5p15. 33 locus …

Background: Poor reporting compromises the reliability and clinical value of prognostic
tumour marker studies. We review articles to assess the reporting of patients and events …

The treatment of glioblastoma multiforme, the most prevalent and lethal form of brain cancer
in humans, has been limited in part by poor delivery of drugs through the blood-brain barrier …

Purpose Glioblastoma (GBM) is the most common and aggressive type of glioma and has
the poorest survival. However, a small percentage of patients with GBM survive well beyond …

Background Glioblastoma is a complex multifactorial disorder that has swift and devastating
consequences. Few genes have been consistently identified as prognostic biomarkers of …

Over the last quarter century there has been significant progress toward identifying certain
characteristics and patterns in GBM patients to predict survival times and outcomes. We …

Some clinically used anti-cancer drugs are obtained from natural products. Allyl
isothiocyanate (AITC), a plant-derived compound abundant in cruciferous vegetables, has …

The pathological and physiological barriers of glioblastoma multiforme (GBM) lead to
insufficient extravasation and penetration of nano-sized therapeutics. As the main driver of …

The median survival time of patients with glioblastoma multiforme (GBM) is 12months, and
only 3–5% of patients survive longer than 3years. We performed histomorphological and …

Two genome-wide association studies of glioma in European populations identified 14
genetic variants strongly associated with risk of glioma, but it is unknown whether these …