The Wnt pathway: from signaling mechanisms to synthetic modulators
The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …
remarkable conservation of this intercellular signaling cascade throughout metazoan …
Cell fate specification and differentiation in the adult mammalian intestine
Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …
Tissue geometry drives deterministic organoid patterning
INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …
have enormous potential as models for human organ development and disease, as …
Wnt signaling pathway: A comprehensive review
Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …
for a variety of physiological processes of an organism's body, including stem cell …
Progress and potential in organoid research
G Rossi, A Manfrin, MP Lutolf - Nature Reviews Genetics, 2018 - nature.com
Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
Tales from the crypt: new insights into intestinal stem cells
The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …
Self-organization and symmetry breaking in intestinal organoid development
Intestinal organoids are complex three-dimensional structures that mimic the cell-type
composition and tissue organization of the intestine by recapitulating the self-organizing …
composition and tissue organization of the intestine by recapitulating the self-organizing …
Wnt signaling in development and tissue homeostasis
Z Steinhart, S Angers - Development, 2018 - journals.biologists.com
The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …
system that is important for stem cell renewal, cell proliferation and cell differentiation both …
[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
[HTML][HTML] Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19
J Ren, L Ding, D Zhang, G Shi, Q Xu, S Shen… - Theranostics, 2018 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including
colorectal cancer (CRC). The crosstalk between carcinoma-associated fibroblasts (CAFs) …
colorectal cancer (CRC). The crosstalk between carcinoma-associated fibroblasts (CAFs) …