With increasing knowledge of immunologic factors and with the advent of potent
immunosuppressive agents, the last several decades have seen significantly improved …

The need for extended second field high-resolution (2F-HR) HLA genotyping in kidney
transplantation is debated. In a cohort of 1000 kidney transplants, we evaluated the impact …

The development of systems biology represents an immense breakthrough in our ability to
perform translational research and deliver personalized and precision medicine. A …

We analyzed in a cohort of 68,606 first deceased donor kidney transplantations reported to
the Collaborative Transplant Study whether an epitope-based matching of donor-recipient …

Development of donor-specific human leukocyte antigen (HLA) antibodies (DSA) remains a
major risk factor for graft loss following organ transplantation, where DSA are directed …

Background Epitope compatibility in deceased donor kidney allocation is an emerging area
of precision medicine (PM), seeking to improve compatibility between donor kidneys to …

Background. Currently, the assessment of immunological risk in lung transplantation (LTx)
does not completely consider HLA compatibility at the molecular level. We have previously …

CD4+ T-helper cells play an important role in alloimmune reactions following transplantation
by stimulating humoral as well as cellular responses, which might lead to failure of the …

Prolonging the lifespan of transplanted organs is critical to combat the shortage of this life‐
saving resource. Chronic rejection, with irreversible demise of the allograft, is often caused …

As the availability of kidneys for transplantation continues to be outpaced by its growing
demand, there has been an increasing utilization of older deceased donors in the last …