Defects in type IV collagen, a collagenous protein involved in the formation of basement
membranes, have been implicated in hereditary Alport's syndrome and acquired …

Four decades have passed since the first discovery of collagen IV by Kefalides in 1966.
Since then collagen IV has been investigated extensively by a large number of research …

Murray and Nadel's Textbook of Respiratory Medicine has long been the definitive and
comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth …

Hereditary familial or congenital nephritis is a definite entity.... Deafness is a marked feature
in nearly all these cases... The male members of a family tend to develop nephritis and …

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by
rapid deterioration of renal function occurring within days or weeks together with signs of …

Laminin and collagen IV are components of most basal laminae (BLs). Recently, both have
been shown to be products of multigene families. The A, B1, and B2 subunits of the laminin …

Neph1-deficient mice develop nephrotic syndrome at birth, indicating the importance of this
protein in the development of a normal glomerular filtration barrier. While the precise …

The glomerular basement membrane (GBM), a principal component of the filtration barrier, is
abnormal in several renal diseases. Notable examples include Alport syndrome …

Mutations in either the COL4A3 or the COL4A4 genes, encoding the α3 and α4 chains of
type IV collagen, are responsible for the autosomal-recessive form of Alport syndrome, a …

The underlying cause of most glomerular diseases remains an enigma. Infectious agents,
autoimmunity, drugs, inherited disorders, and environmental agents have been implicated …