In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents
the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet …

Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become
an essential method for assaying hemostatic competence in liver transplantation, cardiac …

Critically ill patients with COVID-19 pneumonia suffered both high thrombotic and bleeding
risk. The effect of SARS-CoV-2 on coagulation and fibrinolysis is not well known. We …

Objectives: The aim of this study was to determine the frequency of venous
thromboembolism in critically ill coronavirus disease 2019 patients and associate a degree …

Background: Patients with substantive bleeding usually require transfusion and/or (re-)
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …

Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Background: Trauma is a global disease, with over 2.5 million deaths annually from
hemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma, and is associated …

Point-of-care testing (POCT) is a laboratory-medicine discipline that is evolving rapidly in
analytical scope and clinical application. In this review, we first describe the state of the art of …

Background: Low fibrinogen levels are known to occur in trauma. However, the extent of
fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and …