Caffeine is a natural constituent of more than 60 plant species and as such is present in the
human diet through drinks based on plant extracts. It has also been used as a flavoring …

Food-drug interactions can be associated with alterations in the pharmacokinetic and
pharmacodynamic profile of various drugs that may have clinical implications. The various …

Caffeine, theophylline, theobromine, and paraxanthine administered to animals and humans
distribute in all body fluids and cross all biological membranes. They do not accumulate in …

The accuracy of in vitro inhibition parameters in scaling to in vivo drug-drug interactions
(DDI) was examined for over 40 drugs using seven human P450-selective marker activities …

Plasma and salivary caffeine concentrations were measured by gas-liquid chromatography
in 6 healthy caffeine-free volunteers following oral administration of 50, 300, 500 and 750 …

Nonlinear pharmacokinetics (in other words, time or dose dependences in pharmacokinetic
parameters) can arise from factors associated with absorption, first-pass metabolism …

Theophylline is a bronchodllator and respiratory stimulant that is effective in the treatment of
acute and chronic asthma, Cheyne‐Stokes respirations, and apnea/bradycardia episodes in …

In recent years there has been a growing concern over the presence of pharmacologically
active agents and natural toxicants in our food supply. Regulatory agencies have taken the …

The macrolide antibiotics erythromycin and triacetyloleandomycin (troleandomycin) are
prescribed for many types of infections. As such they are often added to other preexisting …

Drug-drug interactions (DDIs) represent a serious problem in clinical practice. However, with
knowledge gained over the past 15 years on the human drugmetabolizing enzymes, a better …