Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Osteoporosis is a chronic disease characterized by an increased risk of fragility fracture.
Patients affected by rheumatic diseases are at greater risk of developing osteoporosis. The …

Sclerostin, a SOST protein secreted by osteocytes, negatively regulates formation of
mineralized bone matrix and bone mass. We report the results of a randomized, double …

Mesenchymal stem cells (MSCs) arise from a variety of tissues, including bone marrow and
adipose tissue and, accordingly, have the potential to differentiate into multiple cell types …

Matricellular proteins are responsible for regulating the microenvironment, the behaviors of
surrounding cells, and the homeostasis of tissues. Periostin (POSTN), a non-structural …

Glucocorticoids (GCs) are highly effective in the treatment of inflammatory and autoimmune
conditions but their therapeutic use is limited by numerous adverse effects. Recent insights …

It is known that prolonged glucocorticoid (GC) treatment results in osteoporosis. This study
aimed to evaluate the protective effects of curcumin on the bones of rats with …

Secondary osteoporosis is commonly caused by long-term intake of glucocorticoids (GCs),
such as dexamethasone (DEX). Diosmin, a natural substance with potent antioxidant and …

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …

Introduction: Sclerostin, a glycoprotein produced primarily by osteocytes, blocks the
canonical Wnt signaling bone formation pathway. Romosozumab is a humanized …