Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

Ulcerative colitis (UC) is an idiopathic relapsing inflammatory disease. Although the etiology
of UC remains unclear, it could be characterized by inflammation of the intestinal mucosa …

Background & Aims Guselkumab, a selective p19 interleukin-23 antagonist, is approved for
the treatment of plaque psoriasis and psoriatic arthritis. This study evaluated the efficacy and …

Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of
patients. Here, we applied single-cell technologies to iCD lesions to address whether …

Molecular mechanisms driving disease course and response to therapy in ulcerative colitis
(UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene …

Mesenchymal stromal cells (MSCs) are currently widely used in cell based therapy
regarding to their remarkable efficacy in controlling the inflammatory status in patients …

Inflammatory bowel disease is characterized by defects in epithelial function and
dysregulated inflammatory signaling by lamina propria mononuclear cells including …

Inflammatory bowel disease (IBD) defines a spectrum of complex disorders. Understanding
how environmental risk factors, alterations of the intestinal microbiota, and polygenetic and …

Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-
sized artery walls. The molecular mechanisms regulating the onset and progression of …

Background and Objective: Altered inflammatory response characterizes chronic
immunemediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory …