Obesity and elevated serum lipids are associated with a threefold increase in the risk of
developing atherosclerosis, a condition that underlies stroke, myocardial infarction, and …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

Oxysterols are cholesterol metabolites now considered bona fide bioactive lipids. Recent
studies have identified new receptors for oxysterols involved in immune and inflammatory …

Oxysterols are oxidized derivatives of cholesterol that are formed enzymatically or via
reactive oxygen species or both. Cholesterol or oxysterols ingested as food are absorbed …

Advanced glycation end products (AGEs) are independently related to cardiovascular
disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells …

Background There is growing evidence that disturbances in cholesterol metabolism may be
involved in major depressive disorder (MDD). However, it is not known if cholesterol …

Total cholesterol (TC) and the cholesterol oxidation product 27-hydroxycholesterol (27-
OHC) are both increased in the elderly. Accumulating evidence has linked 27-OHC to …

The association between plasma lipids and breast cancer (BC) has been extensively
explored although results are still conflicting especially regarding the relationship with high …

Background: Oxysterols are bioactive lipids that control cellular cholesterol synthesis,
uptake, and exportation besides mediating inflammation and cytotoxicity that modulate the …

The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies
have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking …