[HTML][HTML] Ischemia/reperfusion
T Kalogeris, CP Baines, M Krenz… - Comprehensive …, 2016 - ncbi.nlm.nih.gov
Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …
are the most common causes of debilitating disease and death in westernized cultures. The …
Cell biology of ischemia/reperfusion injury
T Kalogeris, CP Baines, M Krenz, RJ Korthuis - International review of cell …, 2012 - Elsevier
Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …
and peripheral vascular disease, continue to be among the most frequent causes of …
[HTML][HTML] Muscle atrophy induced by mechanical unloading: mechanisms and potential countermeasures
Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …
Calpain research for drug discovery: challenges and potential
Y Ono, TC Saido, H Sorimachi - Nature Reviews Drug Discovery, 2016 - nature.com
Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
Functions of autophagy in normal and diseased liver
Autophagy has emerged as a critical lysosomal pathway that maintains cell function and
survival through the degradation of cellular components such as organelles and proteins …
survival through the degradation of cellular components such as organelles and proteins …
[HTML][HTML] ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key Players
The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular
activities and survival. Disturbances in the normal ER functions lead to the accumulation and …
activities and survival. Disturbances in the normal ER functions lead to the accumulation and …
[HTML][HTML] Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
M Juhaszova, DB Zorov, SH Kim… - The Journal of …, 2004 - Am Soc Clin Investig
Environmental stresses converge on the mitochondria that can trigger or inhibit cell death.
Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms …
Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms …
Mitochondrial Ca2+ and regulation of the permeability transition pore
The mitochondrial permeability transition pore was originally described in the 1970's as a
Ca 2+ activated pore and has since been attributed to the pathogenesis of many diseases …
Ca 2+ activated pore and has since been attributed to the pathogenesis of many diseases …
Calcium-mediated cell death during myocardial reperfusion
D Garcia-Dorado, M Ruiz-Meana, J Inserte… - Cardiovascular …, 2012 - academic.oup.com
Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …
Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European …
Ischaemic postconditioning (brief periods of ischaemia alternating with brief periods of
reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces …
reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces …