Encapsulated islets for diabetes therapy: history, current progress, and critical issues requiring solution

DW Scharp, P Marchetti - Advanced drug delivery reviews, 2014 - Elsevier
Insulin therapy became a reality in 1921 dramatically saving lives of people with diabetes,
but not protecting them from long-term complications. Clinically successful free islet implants …

Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond

M Farina, JF Alexander, U Thekkedath, M Ferrari… - Advanced drug delivery …, 2019 - Elsevier
Cell-based therapy is emerging as a promising strategy for treating a wide range of human
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …

Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques

MA Bochenek, O Veiseh, AJ Vegas… - Nature biomedical …, 2018 - nature.com
The transplantation of pancreatic islet cells could restore glycaemic control in patients with
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …

[图书][B] Introduction to nanoscience and nanotechnology

GL Hornyak, HF Tibbals, J Dutta, JJ Moore - 2008 - api.taylorfrancis.com
The maturation of nanotechnology has revealed it to be a unique and distinct discipline
rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry …

[HTML][HTML] Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment

T Qin, AM Smink, P de Vos - Acta Biomaterialia, 2023 - Elsevier
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …

Alginate-based microcapsules for immunoisolation of pancreatic islets

P de Vos, MM Faas, B Strand, R Calafiore - Biomaterials, 2006 - Elsevier
Transplantation of microencapsulated cells is proposed as a therapy for the treatment of a
wide variety of diseases since it allows for transplantation of endocrine cells in the absence …

Cell encapsulation: promise and progress

G Orive, RM Hernández, AR Gascón, R Calafiore… - Nature medicine, 2003 - nature.com
In cell encapsulation, transplanted cells are protected from immune rejection by an artificial,
semipermeable membrane, potentially allowing transplantation (allo-or xenotransplantation) …

Cell encapsulation via microtechnologies

AR Kang, JS Park, J Ju, GS Jeong, SH Lee - Biomaterials, 2014 - Elsevier
The encapsulation of living cells in a variety of soft polymers or hydrogels is important,
particularly, for the rehabilitation of functional tissues capable of repairing or replacing …

Microcapsules and microcarriers for in situ cell delivery

RM Hernández, G Orive, A Murua, JL Pedraz - Advanced drug delivery …, 2010 - Elsevier
In recent years, the use of transplanted living cells pumping out active factors directly at the
site has proven to be an emergent technology. However a recurring impediment to rapid …

Synthetic cells in biomedical applications

W Sato, T Zajkowski, F Moser… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Synthetic cells are engineered vesicles that can mimic one or more salient features of life.
These features include directed localization, sense‐and‐respond behavior, gene …