Multidrug‐resistant bacterial infections have become an important cause of clinical death in
the twenty‐first century. Much effort has been made to overcome this challenge. The …

Ghrelin is an endogenous peptide hormone secreted primarily by the stomach and is
involved in a number of physiological processes including growth hormone secretion, food …

The identification of potent, highly selective orally bioavailable ghrelin receptor inverse
agonists from a spiro-azetidino-piperidine series is described. Examples from this series …

Pyrazolopyrimidinones are fused nitrogen-containing heterocyclic systems, which act as a
core scaffold in many pharmaceutically relevant compounds. Pyrazolopyrimidinones have …

A microwave assisted strategy for synthesis of series of 1H-pyrazolo [4, 3-d] pyrimidin-7 (6H)-
ones has been developed and their biological evaluation as anticancer agents is described …

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of
the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by …

The ghrelin receptor, also referred to as the growth hormone secretagogue receptor 1a
(GHS-R1a), is a G protein-coupled receptor (GPCR) primarily expressed in the brain and …

A new chemotype of ghrelin inverse agonists was discovered through chimeric design
based on molecular scaffolds known as growth-hormone secretagogue receptor (GHSR) …

The optimization for selectivity and central receptor occupancy for a series of spirocyclic
azetidine–piperidine inverse agonists of the ghrelin receptor is described. Decreased …

A transition metal‐free, one step approach has been developed for the synthesis of
pyrazolopyrimidinones using in‐situ condensation of benzylamines, benzylalcohol and …